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To make this comparison, we split the experiment into three regions: Fritzsche , 4,2 F. For small fragments diffusion would reveal a cut, but for long DNA it may be difficult to tell the difference. Abstract The contiguity and phase of sequence information are intrinsic to obtain complete understanding of the genome and its relationship to phenotype. Requirements for obtaining a sharp pattern structure in an image include a movement of the sample at slower rate than the exposure time during imaging. National Center for Biotechnology Information , U. Bottom A magnification of the repetitive part of the molecule. Freitag , 1,2 C. Meandering nanochannel dimensions can easily be tailored to human chromosome scales, which would enable the whole genome to be visualized in seconds. More pertinent to the high-throughput needs of genomics, the longer the length of the genomic DNA to be visualized the longer the time it takes. Such meandering nanochannels enabled us to visualize the complete 5. Journal List Biomicrofluidics v. Sample preparation The experiments were performed with chromosomes from Schizosaccharomyces pombe S.